Research is suggesting that estrogen and estradiol can help keep girls safer when exposed to lead. There is a much higher chance of males suffering the negative consequences of lead exposure and displaying the negative cognitive disabilities. "The findings also add to the evidence that lead exposure has a negative impact on cognitive functioning, especially those functions housed within frontal areas of the brain. Executive functions are controlled largely by the prefrontal cortex, while reading skills rely more heavily on the temporal or parietal areas of the cerebral cortex" (Maya Khanna). From the research that was conducted on a group of children aged 3-6, the found that a larger majority of boys displayed cognitive problems, and they boys lived in older houses that used lead paint. More on this can be found here.
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